Enflurane, isoflurane and the eye.

  • Gavin Earnshaw
  • Published 1984 in Acta anaesthesiologica Scandinavica


The intra-ocular pressure was monitored in ophthalmological patients in whom nitrous oxide/oxygen anaesthesia was supplemented with an inspired concentration of 1% enflurane (10 patients) or 0.7% isoflurane (10 patients). These concentrations are proportionate to 0.6 MAC in oxygen. Both agents caused a significant decrease in intra-ocular pressure, enflurane by a mean of 3.1 mmHg (0.4 kPa) and isoflurane by 2.1 mmHg (0.3 kPa). There was no significant difference between agents. Isoflurane offers an alternative to enflurane in surgery when intra-ocular pressure is of importance.


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